A YY1 Bridge for X Inactivation
نویسندگان
چکیده
Xist RNA inactivates one mammalian X chromosome (the Xi) by associating with it in cis. The mechanism of this interaction is unresolved. Jeon and Lee (2011) now show that YY1 binds both Xist RNA and DNA, thereby providing a mechanism to anchor Xist to the Xi and facilitate X chromosome inactivation.
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ورودعنوان ژورنال:
- Cell
دوره 146 شماره
صفحات -
تاریخ انتشار 2011